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Paroxet is indicated in:
- Major Depressive Disorder
- Obsessive Compulsive Disorder
- Panic Disorder
- Social Anxiety Disorder
- Generalized Anxiety Disorder
- Posttraumatic Stress Disorder.
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✅ Description:
Paroxet works by potentiating serotonergic activity in the central nervous system through the inhibition of neuronal reuptake of serotonin (5-HT). It blocks the uptake of serotonin into human platelets, leading to increased serotonin levels in the brain. It has minimal effects on norepinephrine and dopamine reuptake.
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✔️ Dosage & Administration:
- Dosage varies depending on the condition being treated. Usual initial doses range from 20 mg/day to 40 mg/day, with adjustments made at weekly intervals.
- Maintenance therapy involves periodically reassessing the patient to determine the need for continued treatment.
✔️ Side Effects:
- Side effects vary depending on the indication but may include asthenia, sweating, nausea, decreased appetite, somnolence, dizziness, insomnia, tremor, nervousness, ejaculatory disturbance, and various genital disorders.
✔️ Interaction:
- Food and antacids do not affect the absorption or pharmacokinetics of Paroxet.
- Potential interactions with tryptophan, drug-metabolizing enzyme inducers/inhibitors, alcohol, haloperidol, MAOIs, lithium, phenytoin, anticonvulsants, and warfarin should be considered.
- Concomitant use with MAOIs or thioridazine is contraindicated.
✔️ Pregnancy & Lactation
- Use during pregnancy should be justified by potential benefits outweighing risks to the fetus.
- Caution is advised when administered to nursing mothers due to secretion in human milk.
✔️ Precautions & Warnings:
- Caution is advised in patients with cardiac conditions, epilepsy, or a history of seizures.
- Discontinuation of treatment should be gradual to avoid withdrawal symptoms.
- Dosage adjustments are necessary in elderly, debilitated patients, and those with severe renal or hepatic impairment.
✔️ Use in Special Populations:
- The initial dose for elderly, debilitated patients and those with severe renal or hepatic impairment is 10 mg/day.
✔️ Storage Conditions:
Store at a cool, dry place, protected from light and moisture, and out of reach of children.
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